Asian Journal of Research in Chemistry

S. R. Pattan ¹, R. L. Hullolikar ¹, J. S. Pattan ², N. S. Dighe ¹, M. B. Hole ¹, S. H. Kale ¹, S. B. Bhawar ³

Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Department of Biotechnology, P V P Science College, Pravaranagar, Loni-413713, IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN

Abstract

Fifteen novel derivatives of phenyl thiazole derivatives were synthesized. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc. the structures of the final compounds were confirmed by IR, ¹H-NMR Spectra and CHN analysis. The proposed compounds were screened for their antimicrobial, antifungal, activities with the standard drugs.

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R. Pattan Shashikant ¹, Kekare Prajact ², N. S. Dighe ¹, S. B. Bhawar ³, Nikalje Ana ⁴, Pati Ashwini ⁴, M. B. Hole ¹

Affiliations
1 Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, IN
2 Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum 590 010, IN
3 Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, IN
4 Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad, IN

Abstract

A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, ₁H-NMR and elemental analysis. All the compounds (B₁-B₉) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.

Keywords

Thiazolidinedione, Antidiabetic Activity, Microwave Assisted Synthesis.

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